Saturday, May 16, 2020

Mitochondrial Neurogastrointestinal Encephalopathy Disease...

Zarae Allen Mrs.Willard Honors Biology 1December 2016 Mitochondrial Neurogastrointestinal Encephalopathy Mitochondrial Neurogastrointestinal Encephalopathy disease (MNGIE) is an extremely rare disease that affects the process of muscles and shows up in equal numbers of men and women. Only 70 cases of this disease have been reported. A mutation of the thymidine phosphorylase causes MNGIE and lowers the production of adenosine triphosphate production. To begin, mitochondrial neurogastrointestinal encephalopathy disease is related to adenosine triphosphate because it lowers the production. In a case report on Hindawi called â€Å" Anesthetic Management of a Child with Mitochondrial Neurogastrointestinal Encephalopathy† it states, â€Å" These mutations can result in a decrease in ATP production via oxidative phosphorylation in the respiratory chain found in the mitochondria, affecting tissues that have high energy demands including cardiac, nervous, and skeletal muscle tissue.† An enzyme called thymidine phosphorylase, mutates affecting how ATP is made. As a result, it affec ts the muscle cells of the organism because people with this disorder do not have enough energy to move their muscles in their body. Also, in Genetic Home Reference that had the topic of MNGIE, it reads â€Å"... the muscles and nerves of the digestive system do not move food through the digestive tract efficiently. The resulting digestive problems include feelings of fullness (satiety)

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